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<!-- Creation Date :2022-05-09T14:59:22.5571+00:00 -->
<!-- Copyright (c) 2022 Donnelly Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="gdrx_StockBasedCompensationIncludedInCostsAndOperatingExpensesAbstract" name="StockBasedCompensationIncludedInCostsAndOperatingExpensesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_AccruedBonusAndOtherPayrollRelatedCurrent" name="AccruedBonusAndOtherPayrollRelatedCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="gdrx_AccruedExpensesAndOtherCurrentLiabilities" name="AccruedExpensesAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="gdrx_ConversionOfPreferredStockToCommonStockInConnectionWithInitialPublicOffering" name="ConversionOfPreferredStockToCommonStockInConnectionWithInitialPublicOffering" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="gdrx_EmployeeTaxesPaidRelatedToNetShareSettlementOfEquityAwards" name="EmployeeTaxesPaidRelatedToNetShareSettlementOfEquityAwards" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="gdrx_EntityIncorporationMonthAndYear" name="EntityIncorporationMonthAndYear" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_IncreaseDecreaseOperatingLeaseLiabilities" name="IncreaseDecreaseOperatingLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="gdrx_InvestmentInMinorityEquityInterest" name="InvestmentInMinorityEquityInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="gdrx_LeaseCommencementYear" name="LeaseCommencementYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_LeaseExpirationYear" name="LeaseExpirationYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_LineOfCreditMaximumFinancialCovenantNetLeverageRatio" name="LineOfCreditMaximumFinancialCovenantNetLeverageRatio" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_MinimumLeasePayment" name="MinimumLeasePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="gdrx_NoncashCapitalizedSoftwareDevelopmentCostsInAccruedExpensesAndOther" name="NoncashCapitalizedSoftwareDevelopmentCostsInAccruedExpensesAndOther" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="gdrx_NonCashEmployeeTaxWithholdingObligationsIncludedInAccruedExpensesAndOtherCurrentLiabilities" name="NonCashEmployeeTaxWithholdingObligationsIncludedInAccruedExpensesAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="gdrx_NonCashOfferingCostsIncludedInAccountsPayableAndAccruedExpensesAndOtherCurrentLiabilities" name="NonCashOfferingCostsIncludedInAccountsPayableAndAccruedExpensesAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="gdrx_NoncashPurchaseOfPropertyAndEquipmentIncludedInAccountsPayableAndAccruedExpensesAndOtherCurrentLiabilities" name="NoncashPurchaseOfPropertyAndEquipmentIncludedInAccountsPayableAndAccruedExpensesAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="gdrx_NoncashStockBasedCompensationIncludedInCapitalizedSoftware" name="NoncashStockBasedCompensationIncludedInCapitalizedSoftware" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="gdrx_NumberOfCustomers" name="NumberOfCustomers" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_NumberOfLawsuits" name="NumberOfLawsuits" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_PercentageOfCollateralizedAssetsUnderLineOfCredit" name="PercentageOfCollateralizedAssetsUnderLineOfCredit" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionGrantDateFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="gdrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndSettledInPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndSettledInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardRemainingNumberOfSharesToBeIssued" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardRemainingNumberOfSharesToBeIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_StockIssuedDuringPeriodSharesConversionOfCommonStockToClassOfCommonStock" name="StockIssuedDuringPeriodSharesConversionOfCommonStockToClassOfCommonStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_StockIssuedDuringPeriodSharesConversionOfRedeemablePreferredStockIntoClassOfCommonStock" name="StockIssuedDuringPeriodSharesConversionOfRedeemablePreferredStockIntoClassOfCommonStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_StockIssuedDuringPeriodSharesSaleOfStock" name="StockIssuedDuringPeriodSharesSaleOfStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_StockIssuedDuringPeriodSharesVestingOfRestrictedStockUnits" name="StockIssuedDuringPeriodSharesVestingOfRestrictedStockUnits" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_Stockissuedduringperiodvalueconversionofcommonstockintoclassofcommonstock" name="Stockissuedduringperiodvalueconversionofcommonstockintoclassofcommonstock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="gdrx_StockIssuedDuringPeriodValueConversionOfRedeemablePreferredStockIntoCommonStock" name="StockIssuedDuringPeriodValueConversionOfRedeemablePreferredStockIntoCommonStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="gdrx_StockIssuedDuringPeriodValueSaleOfStock" name="StockIssuedDuringPeriodValueSaleOfStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="gdrx_StockIssuedDuringPeriodValueVestingOfRestrictedStockUnits" name="StockIssuedDuringPeriodValueVestingOfRestrictedStockUnits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="gdrx_UndistributedEarningsLossReallocatedToCommonShareholdersDiluted" name="UndistributedEarningsLossReallocatedToCommonShareholdersDiluted" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="gdrx_UnrecognizedTaxBenefitsThatWouldNotImpactEffectiveTaxRate" name="UnrecognizedTaxBenefitsThatWouldNotImpactEffectiveTaxRate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="gdrx_VariableInterestEntitysPercentageOfTotalAssetsAndLiabilities" name="VariableInterestEntitysPercentageOfTotalAssetsAndLiabilities" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_VariableInterestEntitysPercentageOfTotalRevenue" name="VariableInterestEntitysPercentageOfTotalRevenue" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="gdrx_AccountingPoliciesLineItems" name="AccountingPoliciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_DescriptionOfBusinessLineItems" name="DescriptionOfBusinessLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_CommonClassAAndClassBMember" name="CommonClassAAndClassBMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_ContentLibraryMember" name="ContentLibraryMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_CustomerFourMember" name="CustomerFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_CustomerOneMember" name="CustomerOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_CustomerThreeMember" name="CustomerThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_CustomerTwoMember" name="CustomerTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_DevelopedTechnologyAndTradenameMember" name="DevelopedTechnologyAndTradenameMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_FirstLienCreditAgreementMember" name="FirstLienCreditAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_FirstLienTermLoanFacilityMember" name="FirstLienTermLoanFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_FlipmdIncMember" name="FlipmdIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_GoodrxIncMember" name="GoodrxIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_HealthiNationIncMember" name="HealthiNationIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_OrderBacklogMember" name="OrderBacklogMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_OtherRevenueMember" name="OtherRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_PerformanceAndMarketBasedStockOptionsMember" name="PerformanceAndMarketBasedStockOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_PharmaManufacturerSolutionsRevenuesMember" name="PharmaManufacturerSolutionsRevenuesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_PrescriptionTransactionsRevenueMember" name="PrescriptionTransactionsRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_RestrictedStockAwardsMember" name="RestrictedStockAwardsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_RestrictedStockUnitsForClassACommonStockMember" name="RestrictedStockUnitsForClassACommonStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_RestrictedStockUnitsForClassBCommonStockMember" name="RestrictedStockUnitsForClassBCommonStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_RestrictedStockUnitsPerformanceVestingFounderAwardsMember" name="RestrictedStockUnitsPerformanceVestingFounderAwardsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_RestrictedStockUnitsTimeVestingFounderAwardsMember" name="RestrictedStockUnitsTimeVestingFounderAwardsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_RxnxtLlcMember" name="RxnxtLlcMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_RxSaverIncMember" name="RxSaverIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_ScriptcycleLLCMember" name="ScriptcycleLLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_StockOptionsRestrictedStockAwardsAndRestrictedStockUnitsMember" name="StockOptionsRestrictedStockAwardsAndRestrictedStockUnitsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_SubscriptionRevenueMember" name="SubscriptionRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_VitacarePrescriptionServicesMember" name="VitacarePrescriptionServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_AccountingPoliciesTable" name="AccountingPoliciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_DescriptionOfBusinessTable" name="DescriptionOfBusinessTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="gdrx_PrepaidExpensesAndOtherCurrentAssetsDisclosureTextBlock" name="PrepaidExpensesAndOtherCurrentAssetsDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
</xsd:schema>
